Located in Michigan, Isle Royale National Park consists of a collection of remote islands on Lake Superior. Accessible by ferry or seaplane, this is a great option for those looking to truly get away from civilization for a bit. Unlike some of the other options on this list, Isle Royale is only open seasonally – it'll be reopening for its 2022 on April 15th. Some popular activities at Isle Royale include boating, hiking, and scuba diving.